Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Article Title: Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins

doi: 10.1152/ajpregu.00125.2022

Figure Lengend Snippet: Bioavailability of drug in end of study plasma. Means ± SE. Plasma AUC relative abundance of H4CBD in 45-wk-old LETO ( n = 3), OLETF ( n = 3), and H4CBD-treated OLETF (H4CBD; n = 6). LETO, long Evan’s Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima Fatty.

Article Snippet: Male lean Long Evan’s Tokushima Otsuka (LETO) rats and obese Otsuka Long Evans Tokushima Fatty (OLETF) rats (Japan SLC, Inc., Hamamatsu, Japan), both 14 wk of age, were assigned to the following groups ( n = 8/group): 1 ) vehicle-dosed LETO (LETO), 2 ) vehicle-dosed OLETF (OLETF), and 3 ) H4CBD-treated (200 mg/kg/day × 4 wk) OLETF (H4CBD).

Techniques:

Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Article Title: Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins

doi: 10.1152/ajpregu.00125.2022

Figure Lengend Snippet: H4CBD ameliorated glucose response but not insulin resistance and sensitivity indices in advanced MetS. Mean ± SE. Blood glucose % baseline response to oGTT ( A ) and corresponding AUC (r.u.) ( B ), insulin response % baseline to oGTT ( C ) and corresponding AUC (r.u.) ( D ), insulin resistance index (IRI; relative units) ( E ) and QUICKI in 45-wk-old LETO ( n = 8), OLETF ( n = 8), and H4CBD-treated OLETF (H4CBD; n = 8) ( F ). * P < 0.05 difference from LETO and † P < 0.05 difference from OLETF by one-way or two-way ANOVA with Tukey’s HSD or by unpaired, one-tailed t test. HSD, honestly significant difference; LETO, long Evan’s Tokushima Otsuka; oGTT, oral glucose-tolerance test; OLETF, Otsuka Long-Evans Tokushima Fatty.

Article Snippet: Male lean Long Evan’s Tokushima Otsuka (LETO) rats and obese Otsuka Long Evans Tokushima Fatty (OLETF) rats (Japan SLC, Inc., Hamamatsu, Japan), both 14 wk of age, were assigned to the following groups ( n = 8/group): 1 ) vehicle-dosed LETO (LETO), 2 ) vehicle-dosed OLETF (OLETF), and 3 ) H4CBD-treated (200 mg/kg/day × 4 wk) OLETF (H4CBD).

Techniques: One-tailed Test

Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Article Title: Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins

doi: 10.1152/ajpregu.00125.2022

Figure Lengend Snippet: H4CBD-induced reductions of abdominal fat and plasma adiponectin are positively correlated. Pearson r correlation values of end of study leptin, adiponectin, food intake (FI), epidydimal (Epi) fat, retroperitoneal (Retro) fat, visceral (Epi + Retro) fat, leptin:adiponectin in LETO ( n = 8), OLETF ( n = 8), and H4CBD ( n = 8). LETO, long Evan’s Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima Fatty.

Article Snippet: Male lean Long Evan’s Tokushima Otsuka (LETO) rats and obese Otsuka Long Evans Tokushima Fatty (OLETF) rats (Japan SLC, Inc., Hamamatsu, Japan), both 14 wk of age, were assigned to the following groups ( n = 8/group): 1 ) vehicle-dosed LETO (LETO), 2 ) vehicle-dosed OLETF (OLETF), and 3 ) H4CBD-treated (200 mg/kg/day × 4 wk) OLETF (H4CBD).

Techniques: